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Until May 2000, bivalent A/C meningococcal vaccine was the only available vaccine in Singapore for hajj travelers to Saudi Arabia. Recent worldwide reports of serogroup W-135 meningococcal meningitis associated with hajj returnees necessitated switching to quadrivalent A/C/Y/W-135 vaccine and crossover vaccination of travelers to Saudi Arabia. No safety data are available for quadrivalent vaccine following recent vaccination with bivalent vaccine. We assessed the safety and side effect profile of bivalent, quadrivalent, and quadrivalent meningococcal vaccine after recent vaccination with bivalent vaccine.

journal of travel medicine

Crossover Vaccination with Quadrivalent Meningococcal Vaccine (against A/C/Y/W-135) Following Recent Application of Bivalent Meningococcal Vaccine (against A/C): Assessment of Safety and Side Effect Profile