Early Rabies Antibody Response to Intramuscular Booster in Previously Intradermally Immunized Travelers Using Human Diploid Cell Rabies Vaccine | Zendy

Anthony Gherardin | Zendy; David Scrimgeour | Zendy; Sonny C. Lau | Zendy; Margaret A. Phillips | Zendy; Robert B. Kass | Zendy

Open Access

Early Rabies Antibody Response to Intramuscular Booster in Previously Intradermally Immunized Travelers Using Human Diploid Cell Rabies Vaccine

Author(s) -

Anthony Gherardin,

David Scrimgeour,

Sonny C. Lau,

Margaret A. Phillips,

Robert B. Kass

Publication year - 2006

Publication title -

journal of travel medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.985

H-Index - 59

eISSN - 1708-8305

pISSN - 1195-1982

DOI - 10.2310/7060.2001.24445

Subject(s) - rabies , medicine , rabies vaccine , booster (rocketry) , vaccination , virology , booster dose , rabies virus , immunology , post exposure prophylaxis , lyssavirus , rhabdoviridae , antibody , titer , physics , astronomy

Postexposure treatment (PET) of travelers who may have had a potential rabies exposure is simpler, safer, and cheaper if the traveler is preimmunized. Preimmunization can be done with human diploid cell rabies vaccine (HDCV) administered intramuscularly or intradermally. Some authorities, however, are now advocating that travelers vaccinated by the intradermal (ID) route should be treated as if they are not immunized. A particular concern raised is that travelers who have received pre-exposure rabies vaccination intradermally, may have a delayed response to postexposure boosters. This study is designed to elucidate whether a single intramuscular (IM) HDCV booster will provoke an early (day 5) immune response in individuals given pre-exposure ID HDCV.

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