The Relevance of Mechanistic Data to the Interpretation and Extrapolation to Humans of Rodent Carcinogenicity Data

22. Dietrich DR, Swenberg JA. NCI-Black-Reiter (NBR) male rats fail to develop renal disease following exposure to agents that induce alpha2u-globulin (alpha 2u) nephropathy. Fundam Appl Toxicol 16:749-762 (1991). 23. Lehman-McKeeman LD, Caudill D. Biochemical basis for mouse resistance to hyaline droplet nephropathy: Lack of relevance of the alpha2u-globulin protein superfamily in this male rat specific syndrome. Toxicol Appl Pharmacol 112:214-221 (1992). 24. Lehman-McKeeman LD, Caudill D. Alpha2uglobulin is the only member of the lipocalin protein superfamily that binds to hyaline droplet inducing agents. Toxicol Appl Pharmacol 116:170-176 (1992). 25. Siemiatycki J, Dewar R, Nadon L, Gerin M, Richardson L, Wacholder S. Associations between several sites of cancer and twelve petroleum-derived liquids. Results from a case-referent study in Montreal. Scand J Work Environ Health 13:493-504 (1987). 26. Partanen T, Heikkila P, Hernberg S, Kauppinen T, Moneta G. Renal cell cancer and occupational exposure to chemical agents. Scand J Work Environ Health 17:231-239 (1991). 27. Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene. Arch Toxicol 69:291-299 (1995). 28. Henschler D, Vamvakas S, Lammert M, Dekant W, Kraus B, Thomas B, Ulm K. Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethylene. Arch Toxicol 70:131-133 (1995). 29. McLaughlin JK. Risk factors from a populationbased case-control study of renal cancer. In: Advances in Modern Environmental Toxicology. Renal Effects of Petroleum Hydrocarbons, Vol 7 (Mehlman MA, Hemstreet GP, Thorpe JJ, Weaver NK, eds). Princeton, NJ:Princeton Scientific Publishers, 1984;227-244. 30. McLaughlin JK, Schuman LM. Epidemiology of renal cell carcinoma. Rev Cancer Epidemiol 2:170-210 (1983). 31. McLaughlin JK, Blot WJ, Mehl ES, Stewart PA, Venable FS, Fraumeni JF. Petroleum-related employment and renal cell cancer. J Occup Med 27:672-674 (1985). 32. Dietrich DR, Swenberg JA. Renal carcinogenesis. In: Toxicology of the Kidney (Hook JB, Goldstein RS, eds). New York:Raven Press, 1993;495-537. 33. Green T, Odum J, Nash JA, Foster JR. Perchloroethylene-induced rat kidney tumors: an investigation of the mechanisms involved and their relevance to humans. Toxicol Appl Pharmacol 103:77-89 (1990). 34. Dominick MA, Robertson DG, Bleavins MR, Sigler RE, Bobrowski WF, Gough AW. Alpha 2u-globulin nephropathy without nephrocarcinogenesis in male Wistar rats administered 1(aminomethyl)cyclohexaneacetic acid. Toxicol Appl Pharmacol 111:375-387 (1991). 35. Short BG, Burnett VL, Swenberg JA. Histopathology and cell proliferation induced by 2,2,4-trimethylpentane in the male rat kidney. Toxicol Pathol 14:194-203 (1986). 36. Short BG, Burnett VL, Cox MG, Bus JS, Swenberg JA. Site-specific renal cytotoxicity and cell proliferation in male rats exposed to petroleum hydrocarbons. Lab Invest 57:564-577 (1987). 37. Dietrich DR, Swenberg JA. Lindane induces nephropathy and renal accumulation of alpha 2uglobulin in male but not in female Fischer 344 rats or male NBR rats. Toxicol Lett 53:179-181 (1990). 38. Reuber MD. Carcinogenicity of lindane. Environ Res 19:460-481 (1979). 39. Dolan KP, Unterman R, McLaughlin M, Nakhasi HL, Lynch KR, Feigelson P. The structure and expression of very closely related members of the alpha 2u globulin gene family. J Biol Chem 257:13527-13534 (1982). 40. Chatterjee B, Roy AK. Changes in hepatic androgen sensitivity and gene expression during aging. J Steroid Biochem Mol Biol 37:437-445 (1990). 41. Murty CV, Mancini MA, Chatterjee B, Roy AK. Changes in transcriptional activity and matrix association of alpha 2u-globulin gene family in the rat liver during maturation and aging. Biochim Biophys Acta 949:27-34 (1988). 42. Song CS, Rao TR, Demyan WF, Mancini MA, Chatterjee B, Roy AK. Androgen receptor messenger ribonucleic acid (mRNA) in the rat liver: changes in mRNA levels during maturation, aging, and calorie restriction. Endocrinology 128:349-356 (1991). 43. Roy AK, McMinn DM, Biswas NM. Estrogenic inhibition of the hepatic synthesis of alpha 2u globulin in the rat. Endocrinology 97:1505-1508 (1975). 44. Van Dijck P, Verhoeven G. Interaction of estrogen receptor complexes with the promoter region of genes that are negatively regulated by estrogens: the alpha 2u-globulins. Biochem Biophys Res Commun 182:174-181 (1992). 45. Sippel AE, Feigelson P, Roy A. Hormonal regulation of the hepatic messenger RNA levels for alpha2u globulin. Biochemistry 14:825-829 (1975). 46. Sippel AE, Kurtz DT, Morris HP, Feigelson P. Comparison of in vivo translational rates and messenger RNA levels of alpha2u globulin in rat liver and Morris hepatoma 5123 D. Cancer Res 36:3588-3593 (1976). 47. Chatterjee B, Hopkins J, Dutchak D, Roy AK. Superinduction of alpha2u-globulin by actinomycin D: evidence for drug-mediated increase in A2u mRNA. Proc Natl Acad Sci USA 76: 1833-1837 (1979). 48. Roy AK, Neuhaus OW. Androgenic control of a sex-dependent protein in the rat. Nature 214:618-620 (1967). 49. Mancini MA, Song CS, Rao TR, Chatterjee B, Roy AR. Spatio-temporal expression of estrogen sulfotransferase within hepatic lobule of male rats: implication of in situ estrogen inactivation in androgen action. Endocrinology 131:1541-1546 (1992). 50. Gaworski CL, Haun CC, MacEwen JD, Vernot EH, Bruner RH, Amster RL, Cowan MJ Jr. A 90-day vapor inhalation toxicity study of decalin. Fundam Appl Toxicol 5:785-793 (1985). 51. NTP. Toxicology and Carcinogenesis Studies of d-Limonene (CAS No. 5989-27-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies). TR347. Research Triangle Park, NC:National Toxicology Program, 1990. 52. NTP. Toxicology and Carcinogenesis Studies of Ochratoxin A (CAS No. 303-47-9) in F344/N Rats (Gavage Studies). TR-358. Research Triangle Park, NC:National Toxicology Program, 1989. 53. Montgomery CA, Seely JC. Kidney. In: Pathology of the Fischer Rat (Boorman GA, Eustis SL, Elwell MR, Montgomery CA, MacKenzie WF, eds). San Diego:Academic Press, 1990;127-153. 54. Borghoff SJ, Lagarde WH. Assessment of binding of 2,4,4-trimethyl-2-pentanol to low-molecular-weight proteins isolated from kidneys of male rats and humans. Toxicol Appl Pharmacol 119:228-235 (1993). 55. Borghoff SJ, Strasser JJ, Charbonneau M,. Swenberg JA. Analysis of 2,4,4-trimethyl-2pentanol (TMP-OH) binding to male rat kidney cx2u-globulin (A2u) and other proteins. Toxicologist 8:135 (1988). 56. Borghoff SJ, Upton PB, Swenberg JA. Characteristics of 2,4,4-trimethyl-2-pentanol (TM-POH) binding to A2u-globulin and other compounds that cause protein droplet nephropathy. Toxicologist 9:79 (1989). 57. Lock EA, Charbonneau M, Strasser J, Swenberg JA, Bus JS. 2,2,4-Trimethylpentane-induced nephrotoxicity. II. The reversible binding of a TMP metabolite to a renal protein fraction containing alpha 2u-globulin. Toxicol Appl Pharmacol 91:182-192 (1987). 58. Charbonneau M, Lock EA, Strasser J, Cox MG, Turner MJ, Bus JS. 2,2,4-Trimethylpentaneinduced nephrotoxicity. I. Metabolic disposition of TMP in male and female Fischer 344 rats. Toxicol Appl Pharmacol 91:171-181 (1987). 59. Short BG, Burnett VL, Swenberg JA. Elevated proliferation of proximal tubule cells and localization of accumulated alpha 2u-globulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane. Toxicol Appl Pharmacol 101:414-431 (1989). 60. Borghoff SJ, Youtsey NL, Swenberg JA. A comparison of European high test gasoline and PS-6 unleaded gasoline in their abilities to induce alpha2u-globulin nephropathy and renal cell proliferation. Toxicol Lett 63:21-33 (1992). 61. Bouthillier L, Greselin E, Brodeur J, Viau C, Charbonneau M. Male rat specific nephrotoxicity resulting from subchronic administration of hexachlorobenzene. Toxicol Appl Pharmacol 110:315-326 (1991). 62. Ertuirk E, Lambrecht RW, Peters HA, Cripps DJ, Gocmen A, Morris CR, Bryan GT. Oncogenicity of hexachlorobenzene. In: Hexachlorobenzene: Proceedings of an International Symposium (Morris CR, Cabral JRP, eds). IARC Scientific Publications No 77. Lyon:International Agency for Research on Cancer, 1986;417-423.