Promising Polymers

We have compared the effects of a and recombinant y interferons (IFNs) on the growth of human lung cancer cell lines in vitro. There was a diversity of response amongst the lines studied, the most sensitive being COR-L23 (a large cell anaplastic carcinoma line) and POC (a small cell line). In these two lines. IFN-y was found to be more potent than IFN-a. During cell growth of line POC in the presence of IFN-y no significant shift in cell cycle distribution occurred. When lines COR-L23 and POC were grown as xenograft tumours in nude mice, daily injection of 4 x 105 units per mouse per day of IFN-y produced no discernible retardation of tumour growth.