Human Somatic Mutation Assays As Biomarkers of Carcinogenesis | Zendy

Patricia Compton | Zendy; Kim Hooper | Zendy; Martyn T. Smith | Zendy

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Human Somatic Mutation Assays As Biomarkers of Carcinogenesis

Author(s) -

Patricia Compton,

Kim Hooper,

Martyn T. Smith

Publication year - 1991

Publication title -

environmental health perspectives

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.257

H-Index - 282

eISSN - 1552-9924

pISSN - 0091-6765

DOI - 10.2307/3431307

Subject(s) - carcinogenesis , somatic cell , mutation , biology , carcinogen , germline mutation , computational biology , genetics , cancer research , cancer , gene

This paper describes four assays that detect somatic gene mutations in humans: the hypoxanthine-guanine phosphoribosyl transferase assay, the glycophorin A assay, the HLA-A assay, and the sickle cell hemoglobin assay. Somatic gene mutation can be considered a biomarker of carcinogenesis, and assays for somatic mutation may assist epidemiologists in studies that attempt to identify factors associated with increased risks of cancer. Practical aspects of the use of these assays are discussed.

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