Summary of Discussion Session: EPA Workshop on the SENCAR Mouse in Toxicological Testing

At the EPA Workshop on the SENCAR Mouse in Toxicological Testing, held in Cincinnati, Ohio, on May 1 and 2, 1985, a general discussion was held on the afternoon of the second day. All participants were invited to attend. The discussion was chaired by Richard J. Bull, Washington State University, Pullman, Washington. The focus of discussion was the need for further research. Participants were also encouraged to clarify any questions and raise any issues concerning the papers presented during the previous 11/2 days. The discussion fell into six general subject areas: applications of the SENCAR model, regression and progression of papillomas, comparative pathology of SENCAR mice, basis for the increased sensitivity of the SENCAR, use of SENCAR data in regulatory activities, and statistical evaluation of skin tumor data. This paper summarizes the discussion and organizes the remarks into these six areas.