How frailty models can be used for evaluating longevity limits: Taking advantage of an interdisciplinary approach | Zendy

Anatoli I. Yashin | Zendy; Ivan A. Iachine | Zendy

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How frailty models can be used for evaluating longevity limits: Taking advantage of an interdisciplinary approach

Author(s) -

Anatoli I. Yashin,

Ivan A. Iachine

Publication year - 1997

Publication title -

demography

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.099

H-Index - 129

eISSN - 1533-7790

pISSN - 0070-3370

DOI - 10.2307/2061658

Subject(s) - longevity , covariate , proportional hazards model , survival analysis , hazard , danish , hazard ratio , genetic epidemiology , demography , econometrics , computer science , statistics , population , gerontology , biology , confidence interval , medicine , mathematics , sociology , ecology , philosophy , linguistics

In this paper we discuss an approach to the analysis of mortality and longevity limits when survival data on related individuals with and without observed covariates are available. The approach combines the ideas of demography and survival analysis with methods of quantitative genetics and genetic epidemiology. It allows us to analyze the genetic structure of frailty in the Cox-type hazard model with random effects. We demonstrate the implementation of this strategy to survival data on Danish twins. We then evaluate the resulting lower bounds for biological limits of human longevity. Finally, we discuss the limitations of this approach and directions of further research.

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