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Mycotoxic porcine nephropathy and spontaneous occurrence of ochratoxin A residues in kidneys of slaughtered swine
Author(s) -
Dragan Milićević,
Verica Jurić,
Aleksandra Daković,
Miljan Jovanović,
Srđan Stefanović,
Z Petrović
Publication year - 2009
Publication title -
zbornik matice srpske za prirodne nauke
Language(s) - English
Resource type - Journals
eISSN - 2406-0828
pISSN - 0352-4906
DOI - 10.2298/zmspn0916081m
Subject(s) - ochratoxin a , vacuolization , nephrotoxicity , kidney , nephropathy , ochratoxin , necrosis , medicine , pathology , aristolochic acid , biology , veterinary medicine , endocrinology , food science , mycotoxin , genetics , diabetes mellitus
In order to find information on the occurrence of mycotoxic porcine nephropathy in Serbia, during a six month period (2006/2007) samples of kidney from individual healthy slaughtered pigs were collected (n=90) and analyzed by HPLC for ochratoxin A. In addition, histological examinations were carried out. The incidence of OTA in kidney was 33,3% and varied between 0.17-52.5 ng/g. Histopathological examination of kidneys confirmed tubulopathies with oedema and cell vacuolization. In addition, hemorrhages and necrosis of proximal kidney tubules cells were found. These findings indicate that it is likely that most of the kidney injury is related to ochratoxin A and other nephrotoxic compounds which enhance the toxicity of OTA

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