Experimentally induced invasive aspergillosis in mice | Zendy

Ivana Mirkov | Zendy; Milena Kataranovski | Zendy; Marina Sokovic | Zendy; Jasmina Glamočlija | Zendy; Lidija Zolotarevski | Zendy; Dragan Kataranovski | Zendy

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Experimentally induced invasive aspergillosis in mice

Author(s) -

Ivana Mirkov,

Milena Kataranovski,

Marina Sokovic,

Jasmina Glamočlija,

Lidija Zolotarevski,

Dragan Kataranovski

Publication year - 2007

Publication title -

zbornik matice srpske za prirodne nauke

Language(s) - English

Resource type - Journals

eISSN - 2406-0828

pISSN - 0352-4906

DOI - 10.2298/zmspn0713255m

Subject(s) - aspergillus fumigatus , aspergillosis , spleen , aspergillus , pathology , spore , conidium , hypha , biology , medicine , microbiology and biotechnology , immunology , botany

In this study systemic response to intravenous administration of Aspergillus fumigatus conidia was investigated. The intensity of response was evaluated by a survival rate and by histopathological tissue analysis. Administration of all doses (106 - 5x107) of Aspergillus fumigatus conidia caused mortality, but the highest mortality and the shorter time of survival were noted at higher doses applied. At the highest applied dose, the presence of spores and hyphae was noted in lungs and kidneys. Histological analysis revealed the presence of intense inflammatory reaction in lungs, kidneys and spleen. Functional and histological changes observed provide means to study both mechanisms and drug interventions in systemic Aspergillus infection

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