Worsening of renal function in patients hospitalized with acutely decompensated heart failure

Background/Aims: A predictor of a poor prognosis, renal dysfunction often manifests in patients with heart failure, and is associated with an increased mortality in these patients. The aim of the parent study was to determine risk factors associated with worsening of renal function (WRF) in patients hospitalized for acutely decompensated heart failure Methods: The study included 330 patients with acutely decompensated heart failure. Patients who developed WRF (215, mean age 72.4±9.8) were clinical group, and patients without WRF (115, mean age 59.8±11.7) were control. Patients in the clinical group were observed according to: the age, gender, lipids, electrolytes, smoking, hypertension, and type of heart failure, with reduced or preserved left ventricle ejection fraction (HFrEF or HFpEF). We used logistic regression to calculate non-adjusted ORs and 95% confidence intervals for occurrence of WRF. Results: WRF was determined in 65.2% of patients with heart failure. Non-adjusted OR showed that there was a significant risk for development of WRF with age (OR=4.3; p<0.01), total cholesterol (>5.2 mmol/L) (OR=1.6; p<0.05), hyponatremia (<135 mmol/L), (OR=2.8; p<0.01), smoking (OR=3.9; p<0.01), hypertension (OR=2.0; p<0.05), and with the presence of HFrEF (OR=1.3; p<0.01). Presence of HFpEF, hypokalemia (<3.5 mmol/L), plasma triglycerides (>1.7mmol/L), and gender, did not have any significance for the development of renal damage. Conclusion: We have demonstrated that patients’ age, total cholesterol, hyponatremia, smoking, hypertension, and HFrEF were significant risk factors for worsening of renal function in heart failure patients. Comparing predictive values, age, could be the best prognostic tool for early identification of patients at risk for WRF.