Impact of the hyperbaric oxygen therapy on the redox status in patients with systemic lupus erythematosus | Zendy

Milorad Rabrenović | Zendy; Tamara Nikolić | Zendy; Violeta Rabrenović | Zendy; Jovana Bradić | Zendy; Sasa Tresnjic | Zendy; Anica Petković | Zendy; Biljana Jakovljević | Zendy; Sinisa Masic | Zendy; Dubravko Bokonjić | Zendy

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Impact of the hyperbaric oxygen therapy on the redox status in patients with systemic lupus erythematosus

Author(s) -

Milorad Rabrenović,

Tamara Nikolić,

Violeta Rabrenović,

Jovana Bradić,

Sasa Tresnjic,

Anica Petković,

Biljana Jakovljević,

Sinisa Masic,

Dubravko Bokonjić

Publication year - 2017

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp170110106r

Subject(s) - oxidative stress , medicine , tbars , renal function , superoxide dismutase , creatinine , thiobarbituric acid , endocrinology , lipid peroxidation , chemistry , gastroenterology , immunology

/Aim: Hyperbaric oxygen therapy (HOBT) is a method which increases oxygen solubility in plasma up to 20 times. This effect is very important in the treatment of circulatory disorders, which reduces oxygenation and leads to increased production of inflammatory mediators and free oxygen radicals. The aim of this study was to examine the impact of HBOT on oxidative stress parameters in patients with systemic lupus erythematosus (SLE). Methods: This prospective study included 18 females with SLE (ACR criteria), average age 52.2±8.82 years, treated with HBOT for 60 minutes/day, with average partial oxygen pressure of 2.2 atmospheres absolute (ATA), during 10 days, in combination with appropriate medication therapy for SLE.In serum the following parameters were determined:C-reactive protein (CRP), hemoglobin, creatinine, albumin, complement 3 (C3), antinuclear antibodies (ANA), glomerular filtration rate (GFR using the CKD-EPI formula). In the urine parameters of oxidative stress were spectrofotometrically determined: levels of superoxide anion radical (O2 ), hydrogen peroxide (H2O2), nitrites (NO2 ) and concentration of thiobarbituric acid reactive substances (TBARS). In hemolysate, parameters of antioxidant protection were measured: superoxide dismutase (SOD), catalase (CAT) and reduced gluthatione (GSH). Samples for analysis were collected three times: before HBOT (initial values), after 10 days of HBOT and after 1 month. Results: We noticed statistically significant (p<0,05) decrease in level of O2 , both after 10 days of HBOT and after one month (11.92 ± 6.86; 8.26 ± 13.62; 8.39± 4.94 nmol/ml).Values of other parameters of oxidative stress such as NO2 , TBARS and H2O2 showed no significant difference during the monitored period. Regarding the parameters of antioxidant protection, we revealed slightly higher value of GSH after treatment (66.34±16.31; 79.43±36.77; 69.72 ± 22.32 μmol/ml RBCs) which was held after a month, but it was not statistically significant. Activity of SOD and CAT, before and after HBOT, did not changed significantly. Conclusion: Our results suggested potential beneficial effects of HBOT on redox status in patients with SLE by decreasing levels of O2 .

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