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Background/Aim. Helicobacter (H.) pylori is a widespread bacterium and its   involvement in pathogenesis of gastric diseases is well-known. However, H.   pylori role in etiology of other histologically similar conditions,   especially recurrent aphthous stomatitis (RAS) is still controversial.   Research regarding H. pylori and its association with RAS, as well as the   treatment options were always conducted on patients with diagnosed gastric   problems. The aim of this study was to determine whether H. pylori is present   in the oral cavity of patients suffering from RAS but without any symptoms or   medical history of gastric disease. Methods. A total of 15 patients with RAS   participated in the study. None of the participants suffered from any   gastrointestinal disorders. Two dental plaque samples from each participant   were collected. The first was analyzed using rapid urease test and the second   one was put in transport medium and sent for cultivation. The sensitivity of   H. pylori to antibiotics was established using disk diffusion method of   sensitivity testing for every patient individually and adequate therapy was   prescribed. Results. Before the treatment the mean annual recurrence rate of   RAS was 8.1 ± 2.1, with the average number of lesions being 3.9 ± 1.9. During   the 12-month observation period after the eradication therapy, none of the   patients reported recurrence of aphthous lesions. The treatment was   successful in all cases. Conclusion. This study shows that RAS can be   effectively treated by successful eradication of oral H. pylori, and that RAS   could be possibly considered as an early warning sign of potential gastric   infection by H. pilory

Eradication of Helicobacter pylori in patients without gastric symptoms suffering from recurrent aphthous stomatitis: A pilot study