The distribution of genetic polymorphism of CYP3A5, CYP3A4 and ABCB1 in patients subjected to renal transplantation | Zendy

Neven Vavić | Zendy; Nemanja Rančić | Zendy; Bojana CikotaAleksić | Zendy; Zvonko Magić | Zendy; Jelena Cimesa | Zendy; Katarina Obrenčević | Zendy; Milorad Radojević | Zendy; Momir Mikov | Zendy; Viktorija Dragojević-Simić | Zendy

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The distribution of genetic polymorphism of CYP3A5, CYP3A4 and ABCB1 in patients subjected to renal transplantation

Author(s) -

Neven Vavić,

Nemanja Rančić,

Bojana CikotaAleksić,

Zvonko Magić,

Jelena Cimesa,

Katarina Obrenčević,

Milorad Radojević,

Momir Mikov,

Viktorija Dragojević-Simić

Publication year - 2016

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp150505016v

Subject(s) - tacrolimus , cyp3a5 , transplantation , cyp3a4 , genotype , medicine , pharmacokinetics , kidney transplantation , gastroenterology , genotyping , pharmacology , biology , gene , genetics , cytochrome p450 , metabolism

Polymorphisms of genes which encode transporter P-glycoprotein and most important enzymes for tacrolimus pharmacokinetics can have significant influence reflecting on blood concentrations of this drug. The aim of this study was to examine the distribution of polymorphisms of CYP3A5, CYP3A4 and ABCB1 genes in patients subjected to renal transplantation, for the first time in our transplantation center.

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