Autologous hematopoietic stem cell transplantation in combination with immunoablative protocol in secondary progressive multiple sclerosis: A 10-year follow-up of the first transplanted patient | Zendy

Dragana Obradović | Zendy; Ljiljana Tukić | Zendy; Sanja Radovinović-Tasić | Zendy; Boris Petrovic | Zendy; Marija Elez | Zendy; Gordana Ostojic | Zendy; Bela Balint | Zendy

Open Access

Autologous hematopoietic stem cell transplantation in combination with immunoablative protocol in secondary progressive multiple sclerosis: A 10-year follow-up of the first transplanted patient

Author(s) -

Dragana Obradović,

Ljiljana Tukić,

Sanja Radovinović-Tasić,

Boris Petrovic,

Marija Elez,

Gordana Ostojic,

Bela Balint

Publication year - 2015

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp150304045o

Subject(s) - medicine , multiple sclerosis , expanded disability status scale , transplantation , hematopoietic stem cell transplantation , regimen , surgery , neurology , pediatrics , psychiatry

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that affects young individuals and leads to severe disability. High dose immunoablation followed by autologous hemopoietic stem cell transplantation (AHSCT) has been considered in the last 15 years as potentialy effective therapeutic approach for aggressive MS. The most recent long-time follow-up results suggest that AHSCT is not only effective for highly-aggressive MS, but for relapsing-remitting MS as well, providing long-term remission, or maybe even cure. We presented a 10-year follow-up of the first MS patient being treated by immunoablation therapy and AHSCT.

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