The expression and significance of p53 protein and Ki-67 protein in pterygium | Zendy

Vesna Ljubojević | Zendy; Radoslav Gajanin | Zendy; Ljiljana Amidžić | Zendy; Zoran Vujković | Zendy

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The expression and significance of p53 protein and Ki-67 protein in pterygium

Author(s) -

Vesna Ljubojević,

Radoslav Gajanin,

Ljiljana Amidžić,

Zoran Vujković

Publication year - 2015

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp140428124l

Subject(s) - pterygium , p53 protein , protein expression , cancer research , biology , medicine , genetics , ophthalmology , gene

Pterygium is considered to be a degenerative disease of the conjunctiva, however, the presence of tumor markers in pterygium reinforces the hypothesis that this lesion is similar to tumor. Inactivation of p53 function removes an obstacle to increased proliferation. Factors affecting the prevalence of p53 expression in pterygium deserve investigation. The aim of the study was to investigate the expression of p53 and Ki-67 proteins in pterygium and normal conjunctiva, the effects of gender and age on p53 expression, and the relationship between the expression of p53 and Ki-67 proteins.

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