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Health conditions in Vranje during the Ottoman rule were similar to the situation in the rest of Serbia at that time with poor organized health services. People asked for help for the treatment of "hakims", barbers, doctors and selfeducated folk healers. In the stores that were out of control, in addition to other goods, many medicines, raw materials for making medicines and poisons could be procured from Greece and Turkey. In the 20th century people could still remember various balms, splash, teas, syrups and "madzun" that could be bought in the shops of that time. At the beginning of the 19th century in Vranje, as well as in Serbia, the only help for the sick was provided by Greek self-taught healers, "kaloijatri". There was a self-taught folk healer Mika Stosi who became known in Vranje as "hakim"Mika. "Hakim" Mika died in Constantinople in 1854, where he had gone in order to solve the national status for the Municipality of Vranje . He conveyed his knowledge to his sons Zafir and Dimitrije. Dimitrije was successfully practicing medicine for ten years after his father's death, until a prominent Turk child who was treated by Dimitrije died. Fearing that he would be blamed for the child’s death, "hakim Dimitra " as he was called, committed suicide . A Turkish medical assistant Naum Markovi , who graduated from Medical School in Constantinople, came to Vranje in 1862 . Being a medical assistant (at that time a Turkish title "felcer" was used for this educational degree), he had the right to examine and treat patients and to prepare and sell medicines. In his twofloor house he opened an outpatient department and a pharmacy store where he prepared various preparations in the form of decocts and infusions and many others. Felcer Naum regularly went to Thessaloniki and Constantinople in order to supply his shop with the necessary materials and drugs of herbal, animal and mineral origin. The aim of this paper was to present the historical development of the first community pharmacy in Vranje with the focus on its personnel, legal conditions and pharmacy regulations from the second half of the 19th and the first half of the 20th century. The method of historical analysis was employed. Manual documentary analysis of original sources and desk research analysis from the secondary sources were conducted.

The first pharmacy in Vranje with the educated pharmacist and its development