Protein expression, gene amplification, epidermal growth factor receptor mutations and lung carcinoma | Zendy

Milana Panjković | Zendy; Živka Eri | Zendy; Aleksandra Lovrenski | Zendy; Slavica KneževićUšaj | Zendy; Tatjana Ivković-Kapicl | Zendy

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Protein expression, gene amplification, epidermal growth factor receptor mutations and lung carcinoma

Author(s) -

Milana Panjković,

Živka Eri,

Aleksandra Lovrenski,

Slavica KneževićUšaj,

Tatjana Ivković-Kapicl

Publication year - 2014

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp121031016p

Subject(s) - epidermal growth factor receptor , gene duplication , cancer research , lung , lung cancer , gene , carcinoma , mutation , gene expression , epidermal growth factor , biology , receptor , medicine , pathology , genetics

EGFR belongs to the family of structurally and functionally similar ErbB or HER receptors on cell surfaces, which have intracellular tyrosine kinase activity. What all of these receptors have in common is that they consist of extracellular and membrane components to which ligand and intracellular components are bound via the tyrosine kinase activity . Under normal conditions the activity of ErbB receptors is controled by ligands which belong to the group of EGF related growth factors .

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