English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background/Aim. The cell line C6 is a continuous cell line of rat glioma and,   as a transplantable line, is frequently used for induction into in vivo model   of primary brain tumor. It is believed that, pursuant to its histological   traits and biological behavior, this experimental tumor corresponds to human   anaplastic astrocytoma of grade II/III, which is characterized by   proliferative and invasive potency, and marked cell differentiation. The aim   of this study was to determine macroscopic analysis of rat brain with   implanted tumor during tumorigenesis, histological features of tumor cells of   induced brain tumor and markers of proliferation (proliferation cell nuclear   antigen - PCNA, cytokeratin - CK 19) and differentiation (glial fibrillary   acidic protein -GFAP) in rat brain with implanted tumor. Methods. To   determine histological structure of the brain with implanted C6 cells, we   used brain sections stained for hematoxylin-eosin or kresyl violet, whereas   other sections were immunohistochemically stained for GFAP, CK 19 and PCNA.   Results. A statistically significant difference in weights of the left and   right brain hemispheres with implanted tumors during tumorigenesis in as soon   as 7 days from the day of inducing tumors was revealed. The tumor was of   cellular type, with distinct pleomorphism of cells and frequent   hyperchromasia of the nucleus. Immunohistochemical staining for PCNA revealed   a significant number of positive cells on the days 7, 14 and 21 day following   the implantation of C6 cells. CK 19 positive cells were present in both brain   hemispheres, and numerous GFAP positive astrocytes were found around the   puncture lesion. Conclusions. Within the experimental conditions of the   present research, C6 glioma did not demonstrate any relevant deviations   concerning development, clinical symptomatology and macroscopic anatomy   relative to those already described in the literature

Histological characteristics and markers of proliferation and differentiation in rat brain with experimental glioma