Influence of bile acid derivates on morphine analgesic effect in mice | Zendy

Velibor Vasović | Zendy; Saša Vukmirović | Zendy; Momir Mikov | Zendy; Ivan Mikov | Zendy; Zorana Budakov | Zendy; Nebojša Stilinović | Zendy; Boris Milijašević | Zendy

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Influence of bile acid derivates on morphine analgesic effect in mice

Author(s) -

Velibor Vasović,

Saša Vukmirović,

Momir Mikov,

Ivan Mikov,

Zorana Budakov,

Nebojša Stilinović,

Boris Milijašević

Publication year - 2014

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp121010007v

Subject(s) - morphine , analgesic , pharmacology , medicine , anesthesia

It is known that bile acids improve the absorption, bioavailability and pharmacodynamic characteristics of some drugs. Morphine analgesia is produced by activation of opioid receptors within the central nervous system (CNS) at both spinal and supraspinal levels. Since a morphine molecule contains 3 polar groups and therefore hard to transfer through the blood-brain barrier, the aim of the study was to examine the potential influence of bile acids derivates, namely sodium salt of monoketocholic acid (MKH-Na) and methyl ester of monoketocholic acid (MKH-Me), on analgesic effect of morphine.

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