English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

. Caffeine is indicated in the treatment of migraine headaches,  as well as neonatal apnea and bradycardia syndrome. In mild poisoning, the  most prevalent symptoms are nausea, vomiting, diarrhea, tremor, anxiety and  headache. In more severe cases, symptoms consist of heart rythym  abnormalities, myocardial infarction and seizures. Due to its common  lipolytic effect, caffeine is used in mesotherapy, usually in combination  with drugs of similar effect. We presented a patient with acute iatrogenic  caffeine poisoning. Case report. A 51-year-old woman, with preexisting  hypertension and hypertensive cardiomyopathy was subjected to cosmetic  treatment in order to remove fat by intradermal caffeine injections. During  the treatment the patient felt sickness, an urge to vomit, and a pronounced  deterioration of general condition. Upon examination, the patient exhibited  somnolence, hypotension and nonsustained ventricular tachycardia, which was  sufficient enough evidence for further hospitalization. On admission to the  intensive care unit the patient was anxious with increased heart rate,  normotensive, with cold, damp skin, and visible traces of injection sites  with surrounding hematomas on the anterior abdominal wall. Paroxysmal  supraventricular tachycardia (PSVT) on electrocardiographic monitoring was  found. The laboratory analysis determined a lowered potassium level of 2.1  mmol/L (normal range 3,5 - 5.2 mmol/L), and a toxicological analysis (liquid  chromatography with ultraviolet detection) proved a toxic concentration of  caffeine in plasma - 85.03 mg/L (toxic concentration over 25 mg/L). On  application of intensive therapy, antiarrhythmics, and substitution of  potassium, as well as both symptomatic and supportive therapy, there was a  significant recovery. The patient was discharged without any sequele within  four days. Conclusion. A presented rare iatrogenic acute caffeine poisoning  occured due to massive absorption of caffeine from the subcutaneous adipose  tissue into the circulation when injected directly into the tiny blood  vessels, as evidenced by hematoma formation. Poisoning manifestations were  registered in gastrointestinal, CNS (anxiety, somnolence) and cardiovascular  (hypotension, ventricular tachycardia and nonsustained PSVT) system. In this  era of mesotherapeutic treatment promotion, one should keep in mind toxic  prevention, with application being carried out exclusively in a specialized  institutio

Severe acute caffeine poisoning due to intradermal injections: Mesotherapy hazard