Advantages and limitations of clopidogrel response testing methods | Zendy

Nina Djukanović | Zendy; Zoran Todorović | Zendy; Srdjajegomirovic | Zendy; Miodrag Ostojić | Zendy; Milica Prostran | Zendy

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Advantages and limitations of clopidogrel response testing methods

Author(s) -

Nina Djukanović,

Zoran Todorović,

Srdjajegomirovic,

Miodrag Ostojić,

Milica Prostran

Publication year - 2012

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1204353d

Subject(s) - clopidogrel , medicine , computer science , reliability engineering , engineering , aspirin

Clopidogrel is a thienopyridine that irreversibly inhibits platelet P2Y12 receptors and adenosine diphosphate (ADP) mediated platelet aggregation. It is a prodrug that requires activation in the liver by cytochrome P450 enzymes (CYP3A4, CYP3A5, CYP1A2, CYP2C9, CYP2C19, and/or CYP2B6) . Dual antiplatelet therapy with clopidogrel and aspirin has become the mainstay of treatment of patients with acute coronary syndromes undergoing percutaneous coronary intervention .

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