Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods | Zendy

Vesna Milovanović | Zendy; Biljana Ćirić | Zendy; Jasna Milenkovic | Zendy; Vesna Kilibarda | Zendy; Marijana Ćurčić | Zendy; Slavica Vučinić | Zendy; Biljana Antonijević | Zendy

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Determination of morphine, codeine and 6-monoacetylmorphine in saliva of substance-abuse patients using HPLC/MS methods

Author(s) -

Vesna Milovanović,

Biljana Ćirić,

Jasna Milenkovic,

Vesna Kilibarda,

Marijana Ćurčić,

Slavica Vučinić,

Biljana Antonijević

Publication year - 2012

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1202141m

Subject(s) - codeine , chromatography , saliva , chemistry , morphine , detection limit , high performance liquid chromatography , solid phase extraction , urine , pharmacology , medicine , biochemistry

Saliva represents an alternative specimen for substances abuse determination in toxicology. Hence, the aim of this study was to optimize a method for saliva specimen preparation for heroin metabolites, morphine and 6-monoacetylmorphine (6-mam), and codeine determination by liquid chromatography-mass spectrometry (LC/MS), and to apply this method on saliva samples taken from the patients.

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