Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors | Zendy

Yoshihiko Sakurai | Zendy; Takaji Matsutani | Zendy; Takeshi Yoshioka | Zendy; Tomohiro Takeda | Zendy; Akira Yoshioka | Zendy; Midori Shima | Zendy

Open Access

Alterations of T cell receptor Vβ repertoire of CD8 T lymphocytes in immune tolerance induction in two hemophilia A patients with inhibitors

Author(s) -

Yoshihiko Sakurai,

Takaji Matsutani,

Takeshi Yoshioka,

Tomohiro Takeda,

Akira Yoshioka,

Midori Shima

Publication year - 2011

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1112047s

Subject(s) - t cell receptor , cd8 , immunology , immune system , antibody , t cell , complementarity determining region , peripheral blood mononuclear cell , cytotoxic t cell , medicine , immune tolerance , repertoire , antigen , biology , immunoglobulin light chain , genetics , physics , acoustics , in vitro

Hemophilia A patients with inhibitors are treated effectively with immune tolerance induction (ITI) therapy. Although anti-idiotypic antibodies may play a certain role in the underlying mechanism, the detailed mechanism by which ITI produces a curative effect remains unknown. The aim of this study was to clarify the immunological aspect of ITI.

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