Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos | Zendy

Biljana Antonijević | Zendy; Miloš P. Stojiljković | Zendy; Dubravko Bokonjić | Zendy; Slavica Vučinić | Zendy

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Antidotal effect of combinations obidoxime/HI-6 and memantine in mice poisoned with soman, dichlorvos or heptenophos

Author(s) -

Biljana Antonijević,

Miloš P. Stojiljković,

Dubravko Bokonjić,

Slavica Vučinić

Publication year - 2011

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1112033a

Subject(s) - soman , memantine , dichlorvos , pharmacology , atropine , antidote , chemistry , anesthesia , organophosphate , fasciculation , organophosphate poisoning , pralidoxime , toxicity , medicine , nmda receptor , acetylcholinesterase , biochemistry , biology , agronomy , enzyme , receptor , organic chemistry , pesticide

In acute organophosphate poisoning the issue of special concern is the appearance of muscle fasciculations and convulsions that cannot be adequately antagonised by the use of atropine and oxime therapy. The aim of this study was to examine atidotal effect of obidoxime or HI-6 combinations with memantine in mice poisoned with soman, dichlorvos or heptenophos.

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