Plasma homocysteine levels in patients with liver cirrhosis | Zendy

Djordje Culafic | Zendy; Miroslav Markovic | Zendy; Radmila Obrenović | Zendy; Dragana Mijač | Zendy

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Plasma homocysteine levels in patients with liver cirrhosis

Author(s) -

Djordje Culafic,

Miroslav Markovic,

Radmila Obrenović,

Dragana Mijač

Publication year - 2012

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp110823032c

Subject(s) - homocysteine , cirrhosis , medicine , hypoalbuminemia , methionine , endocrinology , creatinine , catabolism , gastroenterology , biochemistry , metabolism , amino acid , biology

Homocysteine (2-amino-4-mercaptobutyric acid) is an amino acid that may be found in small quantities in all cells, and is quantitatively the major methionine metabolite. The most prevalent form is protein-bound homocysteine (about 80%), mostly to albumins. If catabolism of homocysteine is impaired either due to enzyme defect or deficiency of required intracellular cofactors, homocysteine accumulates in cells and reaches the circulation. The aim of our study was to determine homocysteine values and factors affecting homocysteine metabolism in patients with liver cirrhosis.

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