The influence of CD40 ligation and interferon-γ on functional properties of human monocyte-derived dendritic cells activated with polyinosinic-polycytidylic acid | Zendy

Ana Dragicevic | Zendy; Tanja Džopalić | Zendy; Saša Vasilijić | Zendy; Dragana Vučević | Zendy; Biljana Božić Nedeljković | Zendy; Ivana Majstorović | Zendy; Bela Balint | Zendy; Miodrag Čolić | Zendy

Open Access

The influence of CD40 ligation and interferon-γ on functional properties of human monocyte-derived dendritic cells activated with polyinosinic-polycytidylic acid

Author(s) -

Ana Dragicevic,

Tanja Džopalić,

Saša Vasilijić,

Dragana Vučević,

Biljana Božić Nedeljković,

Ivana Majstorović,

Bela Balint,

Miodrag Čolić

Publication year - 2011

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1104301d

Subject(s) - cd40 , dendritic cell , peripheral blood mononuclear cell , chemistry , monocyte , tlr3 , microbiology and biotechnology , immunology , immune system , biology , innate immune system , toll like receptor , biochemistry , cytotoxic t cell , in vitro

Ligation of a Toll-like receptor (TLR) by specific TLR agonists is a powerful tool for maturation induction of monocyte-derived dendritic cells (MoDCs). Studies so far have shown that the treatment of dendritic cells (DCs) with a TLR3 ligand, polyinosinic-polycytidylicacid [Poly(I:C)], may be an appropriate activation agent for obtaining mature MoDCs, competent to prime effective immune responses. However, little is known about how subsequent interaction of MoDCs with T cell-derived stimuli, such as CD40 or interferon-gamma (IFN-gamma), modulates MoDC functions. Therefore, this problem was the main objective of this study.

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