Simultaneous determination of amoxicillin and clavulanic acid in the human plasma by high performance liquid chromatography: Mass spectrometry (UPLC/MS) | Zendy

Biljana Ćirić | Zendy; Dušan Jandrić | Zendy; Vesna Kilibarda | Zendy; Jasmina Jović-Stošić | Zendy; Viktorija Dragojević-Simić | Zendy; Slavica Vučinić | Zendy

Open Access

Simultaneous determination of amoxicillin and clavulanic acid in the human plasma by high performance liquid chromatography: Mass spectrometry (UPLC/MS)

Author(s) -

Biljana Ćirić,

Dušan Jandrić,

Vesna Kilibarda,

Jasmina Jović-Stošić,

Viktorija Dragojević-Simić,

Slavica Vučinić

Publication year - 2010

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1011887c

Subject(s) - clavulanic acid , chromatography , high performance liquid chromatography , chemistry , amoxicillin , pharmacokinetics , mass spectrometry , liquid chromatography–mass spectrometry , antibiotics , pharmacology , medicine , biochemistry

Quantitative analysis of amoxicillin and clavulanic acid in biological matrices requires sensitive and specific methods which allow determination of therapeutic concentration in 1 g/mL range. Analytical methods for determination of their concentrations in body fluids described in literature include high performance liquid chromatography coupled to UV detector (HPLC-UV) and liquid chromatography-mass spectrometry (LC-MS). The aim of this study was to develop sensitive and specific ultra performance liquid chromatography/mass spectrometry (UPLC/MS) method which could be used for the spectral identification and quantification of the low concentrations of amoxicillin and clavulanic acid in the human plasma.

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