Significance of vascular endothelial growth factor expression in skin melanoma | Zendy

Vesna Gajanin | Zendy; Zdenka Krivokuća | Zendy; Kristina Kostić | Zendy; Radoslav Gajanin | Zendy; Igor Sladojević | Zendy

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Significance of vascular endothelial growth factor expression in skin melanoma

Author(s) -

Vesna Gajanin,

Zdenka Krivokuća,

Kristina Kostić,

Radoslav Gajanin,

Igor Sladojević

Publication year - 2010

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1009747g

Subject(s) - melanoma , medicine , vascular endothelial growth factor , nodular melanoma , angiogenesis , pathology , breslow thickness , metastasis , superficial spreading melanoma , stage (stratigraphy) , mitotic index , lesion , vegf receptors , mitosis , cancer research , cancer , biology , sentinel lymph node , paleontology , breast cancer , microbiology and biotechnology

Melanoma is a heterogeneous disease of skin and mucous membranes which shows significant increase in incidence worldwide in the past decades. In the process of forming new blood vessels stimulators of angiogenesis participate. There is an increase production of vascular endothelial growth factor (VEGF-C and VEGF-D), which expression cause change of endothelial cells, and higher degree of tumor's aggressiveness. The aim of this research was to determine the level of VEGF expression in skin melanoma in different body regions and in different primary stages of the disease.

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