Expression of CD34 in cirrhotic liver: Reliance to dedifferentiation | Zendy

Jasmina Gligorijević | Zendy; Biljana Djordjević | Zendy; Aleksandar Petrović | Zendy; Aleksandra Radičević | Zendy; Simonida Stojanovic | Zendy

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Expression of CD34 in cirrhotic liver: Reliance to dedifferentiation

Author(s) -

Jasmina Gligorijević,

Biljana Djordjević,

Aleksandar Petrović,

Aleksandra Radičević,

Simonida Stojanovic

Publication year - 2010

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp1006459g

Subject(s) - hepatocellular carcinoma , cirrhosis , cd34 , medicine , pathology , cd31 , neovascularization , angiogenesis , immunohistochemistry , gastroenterology , stem cell , biology , genetics

The vascular supply of dysplastic nodules (DN) is altered compared with surrounding cirrhotic nodules. Dysplastic nodules contain unpaired arteries which are isolated arteries unaccompained by bille ducts. In adition, capillarization or neovascularization is evident on CD34 and CD31 staining. The investigation of angiogenic profile of regenerative, dysplastic and nodules of hepatocellular carcinoma aimed at assessing whether vascular profile is in reliance to the process of dedifferentiation of hepatocytes during the course of cirrhosis.

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