Open AccessThe c.-1639g>A polymorphism of the VKORC1 gene and his influence on the therapeutic response during oral anticoagulants use
Author(s) -
Mirjana Kovač,
Ljiljana Rakićević,
A. Maslac,
Dragica Radojković
Publication year - 2009
Publication title -
vojnosanitetski pregled
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.123
H-Index - 19
eISSN - 2406-0720
pISSN - 0042-8450
DOI - 10.2298/vsp0908617k
Subject(s) - vkorc1 , medicine , gene , polymorphism (computer science) , genetics , pharmacology , bioinformatics , biology , genotype , pharmacogenetics
A single nucleotide polymorphism c.-1639G > A in the promoter region of vitamin K-epoxide reductase (VKORC1) gene has been found to account for most of the variability in response to oral anticoagulants (OA). The aim of the study was to determine the incidence and the effect of c.-1639G > A polymorphism on the acenocoumarol dosage requirements in the group of patients under stable anticoagulation, and to estimate the variability in response to OA.
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