Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam | Zendy

Zoran Šegrt | Zendy; Snežana Djordjević | Zendy; Vesna Jaćević | Zendy; Vesna Kilibarda | Zendy; Slavica Vučinić | Zendy; Jasmina Jović-Stošić | Zendy; Olivera Potrebic | Zendy; Natasa Vukcevic-Perkovic | Zendy

Open Access

Pharmacodynamic and pharmacokinetic effects of flumazenil and theophylline application in rats acutely intoxicated by diazepam

Author(s) -

Zoran Šegrt,

Snežana Djordjević,

Vesna Jaćević,

Vesna Kilibarda,

Slavica Vučinić,

Jasmina Jović-Stošić,

Olivera Potrebic,

Natasa Vukcevic-Perkovic

Publication year - 2009

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0902141s

Subject(s) - diazepam , flumazenil , theophylline , sedation , medicine , benzodiazepine , pharmacology , pharmacodynamics , anesthesia , pharmacokinetics , sedative , receptor

The majority of symptoms and signs of acute diazepam poisoning are the consequence of its sedative effect on the CNS affecting selectively poli-synaptic routes by stimulating inhibitory action of GABA. The aim of the present study was to examine the effects of combined application of theophylline and flumazenil on sedation and impaired motor function activity in acute diazepam poisoning in rats.

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