Analysis of Y chromosome microdeletions and CFTR gene mutations as genetic markers of infertility in Serbian men | Zendy

Jelena Dinić | Zendy; Jelena KušićTišma | Zendy; Aleksandra Nikolić | Zendy; Aleksandra Divac Rankov | Zendy; Momčilo Ristanović | Zendy; Dragica Radojković | Zendy

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Analysis of Y chromosome microdeletions and CFTR gene mutations as genetic markers of infertility in Serbian men

Author(s) -

Jelena Dinić,

Jelena KušićTišma,

Aleksandra Nikolić,

Aleksandra Divac Rankov,

Momčilo Ristanović,

Dragica Radojković

Publication year - 2007

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0704253d

Subject(s) - azoospermia factor , y chromosome microdeletion , male infertility , genetics , y chromosome , infertility , azoospermia , biology , chromosome , gene , gene mutation , mutation , pregnancy

Impaired fertility of a male partner is the main cause of infertility in up to one half of all infertile couples. At the genetic level, male infertility can be caused by chromosome aberrations or gene mutations. The presence and types of Y chromosome microdeletions and cystic fybrosis transmembrane conductance regulator (CFTR) gene mutations as genetic cause of male infertility was tested in Serbian men. The aim of this study was to analyze CFTR gene mutations and Y chromosome microdelations as potential causes of male infertility in Serbian patients, as well as to test the hypothesis that CFTR mutations in infertile men are predominantly located in the several last exons of the gene.

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