Damage of tubule cells in diabetic nephropathy type 2: Urinary N-acetyl-β-D-glucosaminidasis and γ-glutamil-transferasis | Zendy

Vlastimir Vlatković | Zendy; Biljana Stojimirović | Zendy; Radmila Obrenović | Zendy

Open Access

Damage of tubule cells in diabetic nephropathy type 2: Urinary N-acetyl-β-D-glucosaminidasis and γ-glutamil-transferasis

Author(s) -

Vlastimir Vlatković,

Biljana Stojimirović,

Radmila Obrenović

Publication year - 2007

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0702123v

Subject(s) - microalbuminuria , proteinuria , medicine , endocrinology , diabetic nephropathy , renal function , kidney , urine , urinary system , type 2 diabetes , nephropathy , chemistry , excretion , urology , diabetes mellitus

A damage of tubular epithelial cells is followed by the release of cell enzymes and production of proinflammatory compounds, which lead to the tubulointerstitial damage. The aim of this study was to examine the function of renal tubules in the patients with diabetes mellitus type 2 (DM type 2) and the various proteinuria degrees, to establish the damage of the proximal tubule cells caused by DM type 2 by determining urinary N-acetyl-beta-D-glucosaminidasis (beta-NAG) and gamma-glutamil-transferasis (gamma-GT) activity in urine, as well as to compare the obtained results in the examined groups of patients with the values in the healthy examinees.

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