Analysis of loss of heterozygosity of the tumor suppressor genes p53 and BRCA1 in ovarial carcinomas | Zendy

Bojana Petrović | Zendy; Milica Perovic | Zendy; Ivaovaković | Zendy; Jasmina Atanacković | Zendy; Branka Popović | Zendy; Ljiljana Luković | Zendy; Spasoje Petkovic | Zendy

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Analysis of loss of heterozygosity of the tumor suppressor genes p53 and BRCA1 in ovarial carcinomas

Author(s) -

Bojana Petrović,

Milica Perovic,

Ivaovaković,

Jasmina Atanacković,

Branka Popović,

Ljiljana Luković,

Spasoje Petkovic

Publication year - 2006

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0609813p

Subject(s) - loss of heterozygosity , carcinogenesis , tumor suppressor gene , microsatellite , biology , gene , ovarian cancer , cancer research , allele , cancer , genetics

Among the genes involved in ovarian carcinogenesis, there has been increased interest in tumor-suppressor genes p53 and BRCA1. Both of the genes make control of cell cycle, DNA repair and apoptosis. The p53 is a "genome guardian" inactivated in more than 50% of human cancers, while BRCA1 mutations are found mostly in breast and ovarian cancer. The aim of this investigation was to establish the frequency of loss of heterozygosity (LOH) in the regions of the genes p53 and BRCA1 in ovarian carcinomas, and to analyze the association of LOH with the disease stage and prognosis.

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