Immunohistochemical analysis of α-SMA and GFAP expression in liver stellate cells | Zendy

Nada Tomanović | Zendy; Ivan Boričić | Zendy; Dimitrije Brašanac | Zendy

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Immunohistochemical analysis of α-SMA and GFAP expression in liver stellate cells

Author(s) -

Nada Tomanović,

Ivan Boričić,

Dimitrije Brašanac

Publication year - 2006

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0606553t

Subject(s) - hepatic stellate cell , pathology , immunohistochemistry , cirrhosis , sma* , glial fibrillary acidic protein , fibrosis , parenchyma , viral hepatitis , hepatitis , biology , medicine , immunology , mathematics , combinatorics

Liver stellate cells play an important role in hepatic fibrosis, and its progression to cirrhosis. These cells show immunoreactivity with different monoclonal antibodies amongst which the commonest are alpha-smooth muscle actin (alpha-SMA) and glial fibrillary acid protein (GFAP). The aim of this study was to analyze stellate cell immunoreactivity for alpha-SMA and GFAP in tissue sections showing the signs of chronic viral B-hepatitis and compare it with those without histopathological changes.

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