Expression of Bcl-2 protein and the amplification of c-myc gene in patients with chronic myeloid leukemia | Zendy

Milica Strnad | Zendy; Goran Brajušković | Zendy; Nataša Strelić | Zendy; Biljana Zivanovic-Todoric | Zendy; Ljiljana Tukić | Zendy; Dragana Stamatović | Zendy

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Expression of Bcl-2 protein and the amplification of c-myc gene in patients with chronic myeloid leukemia

Author(s) -

Milica Strnad,

Goran Brajušković,

Nataša Strelić,

Biljana Zivanovic-Todoric,

Ljiljana Tukić,

Dragana Stamatović

Publication year - 2006

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0604364s

Subject(s) - myeloid leukemia , peripheral blood mononuclear cell , bone marrow , cancer research , fusion gene , haematopoiesis , oncogene , gene , gene expression , microbiology and biotechnology , blast crisis , myeloid , leukemia , alkaline phosphatase , biology , stem cell , immunology , cell cycle , genetics , enzyme , in vitro , biochemistry

Chronic myeloid leukemia (CML) represents a malignant myeloproliferative disease developed out of pluripotent hematopoietic stem cell that contains the fusion bcr-abl gene. Disorders that occur in the process of apoptosis represent one of the possible molecular mechanisms that bring about the disease progress. The aim of our study was to carry out the analysis of the presence of the amplification of the c-myc oncogene, as well as the analysis of the changes in the expression of Bcl-2 in the patients with CML.

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