Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats | Zendy

Maja Jurhar-Pavlova | Zendy; Александар Петличковски | Zendy; Дејан Трајков | Zendy; Оливија Ефинска-Младеновска | Zendy; Todor Arsov | Zendy; Ana Strezova | Zendy; Suzana Dinevska-Kjovkarova | Zendy; Slavcho Mitev | Zendy; Мирко Спироски | Zendy

Open Access

Influence of the elevated ambient temperature on immunoglobulin G and immunoglobulin G subclasses in sera of Wistar rats

Author(s) -

Maja Jurhar-Pavlova,

Александар Петличковски,

Дејан Трајков,

Оливија Ефинска-Младеновска,

Todor Arsov,

Ana Strezova,

Suzana Dinevska-Kjovkarova,

Slavcho Mitev,

Мирко Спироски

Publication year - 2003

Publication title -

vojnosanitetski pregled

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.123

H-Index - 19

eISSN - 2406-0720

pISSN - 0042-8450

DOI - 10.2298/vsp0306657j

Subject(s) - antibody , medicine , immune system , immunoglobulin g , endocrinology , population , immunoglobulin e , chemistry , zoology , immunology , biology , environmental health

The aim of our research was to examine changes in the immune system of the rats influenced by the elevated ambient temperature. Male Wistar rats were divided, into 2 groups and housed at 20 +/- 2 degrees C (n = 64, control group) and 35 +/- 1 degrees C (n = 74, experimental group), during precise timing of 1, 4, 7, 14, 21, and 30 days. All the animals were given food and water ad libitum, and were lighted during 12 hours per day. We have measured IgG, IgG1, IgG2a, IgG2b and IgG2c. The obtained results showed significant elevation in the level of IgG after 4 and 7 days (+32%), IgG2a after 7th (+88%), 14th and 21nd day (+110%), IgG2b after 14 days (+60%) at 35 +/- 1 degrees C compared with the control group at 20 +/- 2 degrees C. IgG1 level was not affected and IgG2c showed significant decrease after 21st day at 35 +/- 1 degrees C. In conclusion, during the elevated ambient temperature the immune system is activated as one of the regulation mechanisms in homeostasis and survival of the population.

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