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Magnesium (Mg) is an essential element that catalyses more than 300 enzyme   systems. Its effects on the central nervous system are exhibited through the   blocking of activity of N-methyl D-aspartat (NMDA) receptors and potentiating   of GABA-ergic neurotransmission. Due to the vast importance of these two   neurotransmission systems in the fine regulation of the central integrative   function activity, the aim of this research was to test the anxiolytic and   antidepressive effects of magnesium, after acute and repeated application,   and its influence on general behavioural parameters. In this research Wistar   albino rats were treated with increasing doses of Mg chloride 6-hydrate (MgCl   10, 20, 30 mg/kg). In order to determine anxiolytic and antidepressive   properties of magnesium two models were used: elevated plus maze (EPM) and   forced swim test (FST). Behavioural parameters (stillness and mobility) were   recorded during acute and repeated administration of the active substance.   Results of EPM testing showed no significant difference between groups,   p>0.05. After acute application of increasing doses of magnesium chloride   hydrate in FST, we showed the statistically significant difference in   immobility time between the group of animals treated with Mg and the control   group treated with the solvent, p<0.01. The statistically significant   difference between groups treated with the lowest and the middle dose of   magnesium and the controls was observed already on the first day of examining   behavioural parameters (p=0.020, p=0.010). Our research has showed that   magnesium, following acute administration, increases locomotor activity, and   has an antidepressive but not an anxiolytic effect

Anxiolytic and antidepressive effects of magnesium in rats and their effect on general behavioural parameters