English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The clinical efficacy of tulathromycin (TU) and florfenicol (FL) in the   treatment of bronchopneumonia (BP) caused by Pasteurella multocida which was   isolated from nose swabs of diseased calves has been examined. The symptoms   of bronchopneumonia (BP) were quantified by means of the clinical score (CS)   with a maximum of 47 points. In the current investigation the average CS in   diseased calves was 23.5± 0.15. The clinical efficacy of TU and FL was   assessed every day in the first week after the administration of the drugs   and was based on the decrease in CS and on microbiological findings on days   7, 28 and 35 after the completion of therapy. Tulathromycin was administered   s.c., in the prescribed therapeutic dose (2.5 mg/kg BW), and florfenicol   s.c., twice at a 48 h interval, in its respective therapeutic dose (40 mg/kg   BW). In spite of the repeated administration of FL, TU was significantly more   rapid to decrease the major clinical symptoms in the first four days   following the application, in comparison with FL (P<0.05). On the fourth day   after the administration, the clinical efficacy of TU in the therapy of BP in   calves was 43.4±1.5 %, and of florfenicol 27.2±1.6 %. However, five days   after the application of TU and two days after the repeated application of FL   the assessed clinical efficacy of the two antibiotics was roughly the same.   The average efficacy of TU was 57.1±0.0%, and of florfenicol 58.5±0.0%, both   the individual and mean CS in the treated calves was 10 points, due to   hyperthermia, which remained the only symptom. Six days after the   administration of TU and three days after the repeated application of FL both   antibiotics had equal maximum efficacy (100%) in the treatment of BP. The   clinical efficacy remained unchanged on day seven. The recovery was confirmed   by the absence of P. multocida in nose swabs sampled on the seventh day after   the initial treatment. However, in 4 calves (21.05 %) of the 19 treated   Streptococcus alpha haemolyticus was isolated. Four weeks after the   completion of the treatment with TU and FL the recurrence of BP caused by P.   multocida was noted in 30% of calves treated with TU and 22.22% with FL.   Seven days after a single administration of TU and FL, all clinical symptoms   of recurrent BP and the microbiological findings were negative. Given the   obtained results of the investigation on the efficacy of TU and FL in calves,   TU can be recommended as the drug of first choice in the treatment of BP   caused by P. multocida. Its insufficient clinical efficacy in the first three   days following the application may be enhanced by simultaneous administration   of NSAID and bronchodilators

Comparative investigation on the efficacy of tulathromycin and florfenicol in the treatment of bronchopneumonia in feedlot calves