Undesired consequences of vaccination and faults in vaccination

Different diseases in domestic animals require the application of different methods of immunological protection, depending on the type of vaccine manner of application and type of adjuvant. The objective of the work was to consider general principles and the basic requirements for efficient vaccination. It points out existing faults in practice which lead to the occurrence of mistakes made during vaccination and the appearance of resulting undesired consequences. There are many reasons why vaccination cannot achieve adequate protection of immunity in the organism. In most cases, this occurs due to the inadequate manner of application of the vaccine or subdosage. Mistakes can occur due to inadequate storage conditions which is an essential factor for maintaining vaccine viability. A special problem is vaccination of pregnant animals and young animals, the vaccination of immunodeficient animals. Risks which follow the implementation of vaccines are existing residual virrulence and toxicity the occurrence of hypersensitivity reactions which tend to appear when inactivated vaccines are applied, the occurrence of diseases in immunodeficient animals. Under certain conditions, vaccines can activate an autoimmune response, but the precise pathogenesis of this syndrome is unclear