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Energy and exergy analysis of a combined refrigeration and waste heat driven  organic Rankine cycle system were studied theoretically in this paper. In  order to complete refrigeration process, the obtained kinetic energy was  supplied to the compressor of the refrigeration cycle. Turbine, in power  cycle, was driven by organic working fluid that exits boiler with high  temperature and pressure. Theoretical performances of proposed system were  evaluated employing five different organic fluids which are R123, R600,  R245fa, R141b and R600a. Moreover, the change of thermal and exergy  efficiencies were examined by changing the boiling, condensing and  evaporating temperatures. As a result of energy and exergy analysis of the  proposed system, most appropriate organic working fluid was determined as  R141b.