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Diabetes mellitus is metabolic syndrome characterized by disorder in  metabolism of carbon hydrates, lipids and proteins. The diagnosis of diabetes  is established by measuring the blood glucose level using standardized  methods. Frequent monitoring of blood glucose level could be inconvenient for  patients because of possible pain during blood sample taking. In the last few  years biological materials with non invasive sampling, like saliva, have been  analyzed. Research has confirmed that some organic and inorganic components  of saliva are modified in diabetic patients (glucose, lipid and protein  components, oxidative stress markers, electrolytes). Beside other markers,  the analysis of glucose in saliva is an attempt to find a non-invasive and  painless way for frequent monitoring of glucose concentration in diabetic  patients. Collecting saliva is simple and economical, it neither requires  expensive equipment nor specially trained staff. Saliva can be taken many  times and in unlimited quantity. In regards to the data about the  possibilities for using saliva as biological sample in monitoring diabetes  mellitus, which could be alternative to blood serum or plasma, the conclusion  is that saliva becomes more important in this context

Biochemical markers in saliva of patients with diabetes mellitus