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Bone is a living tissue, metabolically very active, with the level of   turnover of about 10% per year. Bone remodeling is a well-balanced process of   bone resorption, induced by osteoclasts and bone formation maintained   osteoblasts. Loss of bone remodeling balance, with increased bone resorption,   leads to osteoporosis. Bone turnover markers are classified as markers of   bone formation and of bone resorption. During the growth and development of   skeleton, bone turnover markers show higher levels of activity than in the   adult period. The increase in biochemical markers peaks again in the   postmenopausal period, indicating accelerated bone remodeling. Bone mineral   density is an important predictor of an osteoporotic fracture. Timely   assessment of risk factors of osteoporosis and bone markers can detect   subjects with accelerated bone remodeling and osteoporosis. This may   introduce adequate therapy and prevent fracture

Capture the fracture - use of bone turnover markers in clinical practice