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. The role of tumor necrosis factor-α (TNFα) is well documented   in pathogenesis of chronic periodontitis (CP) and type 2 diabetes (T2D).   Considering short half-life of TNFα, tumor necrosis factor receptor-2 (TNFR2)   is used as prosperous surrogate marker of TNFα activity. Objective. The aim   was to detect TNFR2 serum concentration and correlate it with periodontal   destruction in patients with diagnosed T2D and nondiabetics. Methods. The   study included 85 patients divided into three groups: T2D + CP (group T2D, n   = 34); nondiabetics + CP (Group PD, n = 27); and healthy controls (group HC,   n = 24). T2D was diagnosed according to WHO criteria (2013) and periodontitis   was diagnosed using International Workshop for a Classification of   Periodontal Diseases and Conditions criteria (1999). TNFR2 level was measured   by enzyme-linked immunosorbent assay (ELISA). Results. There was no   difference in TNFR2 level among the groups (Kruskal-Wallis, p = 0.482).   Significant correlation (Pearson’s correlation coefficient) was observed   between clinical attachment loss (CAL) and TNFR2 concentration in PD group   (rp = -0.460, p = 0.016). In T2D group, correlations were observed between   TNFR2 concentration and CAL (rp = 0.363, p = 0.005) and periodontal inflamed   surface area (PISA) (rp = 0.345, p = 0.046) and periodontal epithelial   surface area (PESA) (rp = 0.578, p = 0.000). Conclusion. Higher concentration   of TNFR2 was associated with higher CAL, PESA, and PISA scores in T2D group.   Contrary to that, nondiabetics with higher values of CAL exhibited lower   concentration of TNFR2, presenting potential protective effect on periodontal   destruction. These results imply that diabetes may alter TNFR2 secretion   originated from periodontium. [Projekat Ministarstva nauke Republike Srbije,   br. 41008

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Relationship between serum tumor necrosis factor receptor-2 concentration and periodontal destruction in patients with type 2 diabetes: Cross-sectional study