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. In spite of the wide usage of corticosteroids for the treatment  of a plethora of diseases, sometimes they can induce immediate  hypersensitivity reactions, which are however uncommon. Case Outline. We  report a case of immediate allergic reaction induced by intravenous  methylprednisolone given before operation for surgical repair of an arm  contracture as a sequel of burns, which the child had tolerated a month  before. Six weeks later the patient repeated the anaphylactic reaction during  skin testing to methylprednisolone. In addition, basophile activation test  with methylprednisolone (BAT) was positive. Conclusion. This case report  describes a patient who experienced intraoperative anaphylaxis and  anaphylactic reaction induced by skin testing. This is the first report on  induction of both anaphylactic reactions by methylprednisolone in the same  child. Clinical findings, positive BAT and positive skin tests with  methylprednisolone imply that the child developed type-I hypersensitivity.  The lack of cross-reactivity with other corticosteroids emphasizes that the  reactions were caused by the steroid molecule

Immediate allergic reaction to methylprednisolone with tolerance of other corticosteroids