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. Allogeneic stem-cell transplantation is only potentially   curative therapy for variety of hematology malignancies, such as acute and   chronic leukemia, myelodisplastic syndrome and aplastic anemia, but also   promising treatment option for other disorders. If we know that only 25% of   patients have an human leukocyte antigen identical sibling donor, it is   obvious that matched unrelated donor hematopoietic stem cell transplantation   is an alternative for the rest of the patients. Material and Methods. Since   2013, matched unrelated donor hematopoietic stem cell transplantation has   been performed routinely in the Military Medical Academy. Results. We hereby   present the outcome after 77 procedures in 75 patients. Considering primary   diseases, 35 patients had acute myeloid leukemia, 25 patients had acute   lymphoid leukemia, 5 patients had chronic myeloid leukemia, 9 patients had   myelodisplastic syndrome and we performed the transplant on 1 patient with   chronic lymphocyte leukemia, 1 patient with aplastic anemia and 1 patient   with T lymphoblastic lymphoma. Conclusion. It is difficult to make clear   conclusions based on this heterogeneous group of patients, but it seems that   these results are encouraging. Future research will be performed to evaluate   matched unrelated donor and identical sibling hematopoietic stem cell   transplantation in the homogenous groups with respect to primary diseases.

Matched unrelated donor hematopoietic stem cell transplantation - our results