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. Mathematical formulas, such as homeostatic model assessment   indexes, proved to be useful for the estimation of insulin resistance.   Nevertheless, numerous published results point to a considerable   variability of their reference values. The aim of this study was to use   homeostatic model assessment indexes and evaluate levels of insulin   resistance in nondiabetic patients. Material and Methods. The study   included 486 individuals (mean age 36.84 ? 12.86; 17% of males and 83% of   females). Blood sampling was performed in order to determine glucose and   insulin plasma levels, at the 0th and 120th minute of the oral glucose   tolerance test. The indexes were calculated by the use of homeostatic model   assessment 2 calculator, homeostatic model assessment of insulin resistance,   homeostatic model assessment of insulin sensitivity, and homeostatic model   assessment of ?-cells function. The results were statistically analyzed   using a Data Analysis programme. Results. In the examined population, the   average glycemic values of the oral glucose tolerance test were within the   euglycemic scope (Gluc 0 = 4.76 ? 0.45 mmol/L; Gluc 120 = 5.24 ? 1.17   mmol/L), while the average values of calculated homeostatic model   assessment indexes were: insulin resistance - 1.41 ? 0.82; ?-cells function   - 131.54 ? 49.41%, and insulin sensitivity - 91.94 ? 47.32%. According to   study cut-off values, homeostatic model assessment of insulin resistance   was less than 2. We found 84 (17.28%) individuals with increased insulin   resistance. Also, we set the lowest reference value for homeostatic model   assessment of insulin sensitivity at less than 50%. With the probability   of 66.67% (x? ? 1SD), basal insulin level under 11.9 mIU/L can be considered   to correspond to physiologic level of insulin resistance. Conclusion. The   follow-up of increased insulin resistance and altered secretion of   pancreatic ?-cells, at early stages of glucose regulation disturbances, may   be useful in assessing dynamics and level of glucose regulation disturbances   and their appropriate treatment.This article has been corrected. Link to the correction   10.2298/MPNS1708202E

Significance and role of homeostatic model assessment in the evaluation of glucose regulation mechanisms