A case of severe ADAMTS 13 deficiency presenting as thrombotic thrombocytopenic purpura in pregnancy | Zendy

Marinos Nikolaou | Zendy; Μαρίνα Καρακάντζα | Zendy; George Adonakis | Zendy; Γεώργιος Θεοδώρου | Zendy; Nikolaos Zoumbos | Zendy; George Decavalas | Zendy

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A case of severe ADAMTS 13 deficiency presenting as thrombotic thrombocytopenic purpura in pregnancy

Author(s) -

Marinos Nikolaou,

Μαρίνα Καρακάντζα,

George Adonakis,

Γεώργιος Θεοδώρου,

Nikolaos Zoumbos,

George Decavalas

Publication year - 2012

Publication title -

medicinski pregled

Language(s) - English

Resource type - Journals

eISSN - 1820-7383

pISSN - 0025-8105

DOI - 10.2298/mpns1210436n

Subject(s) - medicine , adamts13 , thrombotic thrombocytopenic purpura , pregnancy , microangiopathic hemolytic anemia , von willebrand factor , gestation , thrombocytopenic purpura , pediatrics , platelet , biology , genetics

Thrombotic thrombocytopenic purpura is a rare life-threatening disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia. It is caused by the absent or severe deficiency of the von Willebrand Factor-cleaving protease named ADAMTS13. Pregnancy is a well recognized factor precipitating the appearance of the disease both in women that had reduced levels of ADAMTS13 activity prior to gestation and in those with other inherited or acquired thrombophilic syndromes.

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