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Since without prospective randomized studies it is not possible to have a  clear attitude towards the importance of intracranial pressure monitoring,  this study was aimed at examining the prognostic effect of the intracranial  pressure monitoring and intracranial pressure oriented therapy in severe  brain trauma patients, and at defining optimal intracranial pressure values  for starting the treatment. Two groups of patients were treated in the study,  one consisted of 32 patients undergoing intracranial pressure monitoring and  the second group of 29 patients without intracranial pressure monitoring in  the control group. The study was prospective with groups randomized. There  were 53% survivals in the intracranial pressure monitored patients and 34% in  the control group, with no significant difference in the survival rate  between the two groups (χ2=2.11; p=0.15; p>0.05). The average intracranial  pressure in the patients with intracranial hypertension who died was 27 mm  Hg, while in the patients who survived the average intracranial pressure was  significantly lower (Student’s t test: t=2.91; p=0.008; p<0.01) and it was 18  mm Hg. We recommend starting intracranial pressure oriented therapy when the  patient’s intracranial pressure exceeds 18 mmHg during 2 hours of monitoring

Prognostic significance of intracranial pressure monitoring and intracranial hypertension in severe brain trauma patients