Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution | Zendy

Nina Božinović | Zendy; Bogdan A. Šolaja | Zendy; Igor Opsenica | Zendy

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Microwave-assisted synthesis of azepines via nucleophilic aromatic substitution

Author(s) -

Nina Božinović,

Bogdan A. Šolaja,

Igor Opsenica

Publication year - 2016

Publication title -

journal of the serbian chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.227

H-Index - 45

eISSN - 1820-7421

pISSN - 0352-5139

DOI - 10.2298/jsc160824074b

Subject(s) - nucleophilic aromatic substitution , nucleophilic substitution , microwave irradiation , substitution reaction , chemistry , combinatorial chemistry , catalysis , nucleophile , microwave , substitution (logic) , radical nucleophilic aromatic substitution , organic chemistry , computer science , telecommunications , programming language

A novel and efficient route has been developed to afford 5H-dipyridoazepine derivatives from primary amines and 3,3'-(Z)-ethene-1,2-di-ylbis(4-chloropyridine). The procedure based on the double nucleophilic aromatic substitution provides a valuable synthetic tool for the synthesis of dipyridoazepines. The reaction proceeds without catalyst, under microwave irradiation condition. [Projekat Ministarstva nauke Republike Srbije, br. 172008

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